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CAS No.: 553-21-9

木香烃内酯 Catalog No. CSN16398

Synonyms: (+)-Costunolide;Costus lactone;NSC 106404

Costunolide shows anti-inflammatory and anti-oxidant activities and also induces apoptosis. It is a sesquiterpene lactone isolated from stem bark of Magnolia sieboldii,

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生物活性

描述Costunolide, a natural sesquiterpene lactone, is found commonly in many species such as Saussurea lappa and Artemisia balchanorum. Besides, it has a variety of biological activities, such as chemopreventive and antitumor activity, anti-inflammatory, antibiotic, anti-fungal and anti-viral activity of costunolide^[3]. Costunolide caused inhibition of cell growth of human breast carcinoma cell lines MCF-7 cells and MDA-MB-231 cells with IC₅₀ of 90 mM and 50 mM, respectively, and this effect was mediated at least in part by costunolide-induced significant reduction in telomerase activity^[4]. Costunolide treatment at 40 mg/kg on acute liver injury (ALI) mice significantly improved the pathological changes of hepatic tissue, and reduced the LPS and D-galactosamine-induced increases of alanine aminotransferase (from 887.24 ± 21.72 to 121.67 ± 6.56 IU/L) and aspartate aminotransferase (from 891.01 ± 45.24 to 199.94 ± 11.53 IU/L) activities in serum, remarkably reduced malondialdehyde content (from 24.56 ± 1.39 to 9.17 ± 0.25 nmol/ml) and reactive oxygen species (from 203.34 ± 7.68 to 144.23 ± 7.12%), increased the activity of anti-oxidant enzymes superoxide dismutase (from 153.74 ± 10.33 to 262.27 ± 8.39 U/ml), catalase (from 6.12 ± 0.30 to 12.44 ± 0.57 U/ml), and total anti-oxidant capacity (from 0.64 ± 0.06 to 6.29 ± 0.11 U/ml) in hepatic tissues^[5]. CHO cells treated with 5.01 μM Costunolide showed slightly higher micronuclei compared to the untreated cells, and Costunolide at 5.01, 7.56, and 10.12 μM concentrations significantly inhibited tubulin polymerization by 64.89, 50.86, and 41.63%, respectively, in comparison to the control^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.3044 mL
- 21.5222 mL
- 43.0444 mL
- 5 mM
- 0.8609 mL
- 4.3044 mL
- 8.6089 mL
- 10 mM
- 0.4304 mL
- 2.1522 mL
- 4.3044 mL

技术信息

CAS号

553-21-9

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H20O2

运输

蓝冰

分子量

232.32

别名

(+)-Costunolide;Costus lactone;NSC 106404;Melampolide;CCRIS 6754;木香烃内酯

溶解度

DMSO	170.0 mg/mL (731.8 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	3.4 mg/mL	clear
PO	0.5% CMC-Na	66 mg/mL	suspension

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